| pubmed-article:19411069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C1823882 | lld:lifeskim |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C1523298 | lld:lifeskim |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C1519616 | lld:lifeskim |
| pubmed-article:19411069 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19411069 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19411069 | pubmed:dateCreated | 2009-5-4 | lld:pubmed |
| pubmed-article:19411069 | pubmed:abstractText | Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival. Enforced expression of YB-1 in noninvasive breast epithelial cells induced an epithelial-mesenchymal transition (EMT) accompanied by enhanced metastatic potential and reduced proliferation rates. YB-1 directly activates cap-independent translation of messenger RNAs encoding Snail1 and other transcription factors implicated in downregulation of epithelial and growth-related genes and activation of mesenchymal genes. Hence, translational regulation by YB-1 is a restriction point enabling coordinated expression of a network of EMT-inducing transcription factors, likely acting together to promote metastatic spread. | lld:pubmed |
| pubmed-article:19411069 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19411069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19411069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19411069 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19411069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19411069 | pubmed:month | May | lld:pubmed |
| pubmed-article:19411069 | pubmed:issn | 1878-3686 | lld:pubmed |
| pubmed-article:19411069 | pubmed:author | pubmed-author:SorensenPoul... | lld:pubmed |
| pubmed-article:19411069 | pubmed:author | pubmed-author:OvchinnikovLe... | lld:pubmed |
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| pubmed-article:19411069 | pubmed:author | pubmed-author:EvdokimovaVal... | lld:pubmed |
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| pubmed-article:19411069 | pubmed:author | pubmed-author:SorokinAlexey... | lld:pubmed |
| pubmed-article:19411069 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19411069 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:19411069 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19411069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19411069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19411069 | pubmed:pagination | 402-15 | lld:pubmed |
| pubmed-article:19411069 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19411069 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19411069 | pubmed:articleTitle | Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. | lld:pubmed |
| pubmed-article:19411069 | pubmed:affiliation | Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada. v.evdokimova@gmail.com | lld:pubmed |
| pubmed-article:19411069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19411069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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