|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2009-5-4
|
|
pubmed:abstractText |
Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival. Enforced expression of YB-1 in noninvasive breast epithelial cells induced an epithelial-mesenchymal transition (EMT) accompanied by enhanced metastatic potential and reduced proliferation rates. YB-1 directly activates cap-independent translation of messenger RNAs encoding Snail1 and other transcription factors implicated in downregulation of epithelial and growth-related genes and activation of mesenchymal genes. Hence, translational regulation by YB-1 is a restriction point enabling coordinated expression of a network of EMT-inducing transcription factors, likely acting together to promote metastatic spread.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Caps,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Y-Box-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/YBX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/snail family transcription factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1878-3686
|
|
pubmed:author |
pubmed-author:DavicioniElaiE,
pubmed-author:EvdokimovaValentinaV,
pubmed-author:FinkDieterD,
pubmed-author:MelnykNatalyaN,
pubmed-author:NgTonyT,
pubmed-author:OvchinnikovLev PLP,
pubmed-author:RuzanovPeterP,
pubmed-author:SorensenPoul H BPH,
pubmed-author:SorokinAlexeyA,
pubmed-author:TognonCristinaC,
pubmed-author:TricheTimothy JTJ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
5
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
402-15
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19411069-Animals,
pubmed-meshheading:19411069-Breast Neoplasms,
pubmed-meshheading:19411069-Cadherins,
pubmed-meshheading:19411069-Cell Differentiation,
pubmed-meshheading:19411069-Cell Line, Tumor,
pubmed-meshheading:19411069-Cell Proliferation,
pubmed-meshheading:19411069-DNA-Binding Proteins,
pubmed-meshheading:19411069-Epithelial Cells,
pubmed-meshheading:19411069-Humans,
pubmed-meshheading:19411069-Mesoderm,
pubmed-meshheading:19411069-Mice,
pubmed-meshheading:19411069-Neoplasm Invasiveness,
pubmed-meshheading:19411069-Nuclear Proteins,
pubmed-meshheading:19411069-Protein Biosynthesis,
pubmed-meshheading:19411069-RNA, Messenger,
pubmed-meshheading:19411069-RNA Caps,
pubmed-meshheading:19411069-Transcription Factors,
pubmed-meshheading:19411069-Y-Box-Binding Protein 1
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.
|
|
pubmed:affiliation |
Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada. v.evdokimova@gmail.com
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
