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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2009-6-15
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pubmed:abstractText |
Stromal cell-derived factor-1 (SDF-1) and its unique receptor, CXCR4, regulate stem/progenitor cell migration and retention in the bone marrow and are required for hematopoiesis. Recent studies found that hERG1 K(+) channels were important regulators of tumor cell migration. In this study, we investigated whether SDF-1 induced acute leukemic cell migration associated with hERG1 K(+) channels. Our results showed that E-4031, a specific hERG1 K(+) channels inhibitor, significantly blocked SDF-1-induced migration of leukemic cell lines, primary acute leukemic cells, leukemic stem cells and HEK293T cells transfected with herg-pEGFP. The migration of phenotypically recognizable subsets gave the indication that lymphoblastic leukemic cells were inhibited more than myeloid cells while in the presence of E-4031 which maybe associated with herg expression. SDF-1 increased hERG1 K(+) current expressed in oocytes and HEK293T cells transfected with herg-pEGFP. There were no significant changes of CXCR4 expression on both HL-60 cells and primary leukemic cells regardless if untreated or treated with E-4031 for 24 h (P>0.05). The hERG1 K(+) current increased by SDF-1 might contribute to the mechanism of SDF-1-induced leukemic cell migration. The data suggested that hERG1 K(+) channels functionally linked to cell migration induced by SDF-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1090-2422
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pubmed:author |
pubmed-author:AntónM PMP,
pubmed-author:ChenXiangjunX,
pubmed-author:DuYi-MeiYM,
pubmed-author:FanLinglingL,
pubmed-author:GuoLinlinL,
pubmed-author:HuangShiangS,
pubmed-author:JieShenghuaS,
pubmed-author:LiHuiyuH,
pubmed-author:MaY LYL,
pubmed-author:TomP APA,
pubmed-author:ZhangSongyuS,
pubmed-author:ZhuJiangJ
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
315
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2256-64
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pubmed:meshHeading |
pubmed-meshheading:19409379-Adolescent,
pubmed-meshheading:19409379-Adult,
pubmed-meshheading:19409379-Aged,
pubmed-meshheading:19409379-Animals,
pubmed-meshheading:19409379-Anti-Arrhythmia Agents,
pubmed-meshheading:19409379-Cell Movement,
pubmed-meshheading:19409379-Chemokine CXCL12,
pubmed-meshheading:19409379-Child,
pubmed-meshheading:19409379-Child, Preschool,
pubmed-meshheading:19409379-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:19409379-Female,
pubmed-meshheading:19409379-HL-60 Cells,
pubmed-meshheading:19409379-Humans,
pubmed-meshheading:19409379-Male,
pubmed-meshheading:19409379-Middle Aged,
pubmed-meshheading:19409379-Neoplastic Stem Cells,
pubmed-meshheading:19409379-Oocytes,
pubmed-meshheading:19409379-Piperidines,
pubmed-meshheading:19409379-Pyridines,
pubmed-meshheading:19409379-Receptors, CXCR4,
pubmed-meshheading:19409379-Xenopus laevis,
pubmed-meshheading:19409379-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration.
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pubmed:affiliation |
Center for Stem Cell Research and Application, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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