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pubmed-article:19392797pubmed:abstractTextCytokine single nucleotide polymorphisms and consequent production levels have been associated with acute graft-vs-host disease (aGVHD) development. The aim of this pilot study was to determine whether polymorphisms in tumor necrosis factor (TNF), lymphotoxin alpha (LTA) and transforming growth factor beta 1 (TGFB1) showed any association with aGVHD severity. Novel alleles and polymorphisms were identified for each cytokine locus. Genotype distributions were examined in 38 recipient-donor pairs (all chronic myelogenous leukemia in the first chronic phase) with either low-grade (grades 0-I) or high-grade (grades III-IV) aGVHD. Although no significant differences were found, some trends were noted in genotype distributions among aGVHD-grade groups. Power calculations determined that substantially more pairs would be required to show significant associations in distributions among aGVHD-grade groups.lld:pubmed
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pubmed-article:19392797pubmed:articleTitleTNF, LTA and TGFB1 genotype distributions among acute graft-vs-host disease subsets after HLA-matched unrelated hematopoietic stem cell transplantation: a pilot study.lld:pubmed
pubmed-article:19392797pubmed:affiliationDepartment of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.lld:pubmed
pubmed-article:19392797pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19392797pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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