Source:http://linkedlifedata.com/resource/pubmed/id/19392797
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-6-15
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| pubmed:abstractText |
Cytokine single nucleotide polymorphisms and consequent production levels have been associated with acute graft-vs-host disease (aGVHD) development. The aim of this pilot study was to determine whether polymorphisms in tumor necrosis factor (TNF), lymphotoxin alpha (LTA) and transforming growth factor beta 1 (TGFB1) showed any association with aGVHD severity. Novel alleles and polymorphisms were identified for each cytokine locus. Genotype distributions were examined in 38 recipient-donor pairs (all chronic myelogenous leukemia in the first chronic phase) with either low-grade (grades 0-I) or high-grade (grades III-IV) aGVHD. Although no significant differences were found, some trends were noted in genotype distributions among aGVHD-grade groups. Power calculations determined that substantially more pairs would be required to show significant associations in distributions among aGVHD-grade groups.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1399-0039
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
74
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
50-6
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| pubmed:dateRevised |
2011-11-14
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| pubmed:meshHeading |
pubmed-meshheading:19392797-Adolescent,
pubmed-meshheading:19392797-Adult,
pubmed-meshheading:19392797-Female,
pubmed-meshheading:19392797-Gene Frequency,
pubmed-meshheading:19392797-Genetic Predisposition to Disease,
pubmed-meshheading:19392797-Genotype,
pubmed-meshheading:19392797-Graft vs Host Disease,
pubmed-meshheading:19392797-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19392797-Humans,
pubmed-meshheading:19392797-Lymphotoxin-alpha,
pubmed-meshheading:19392797-Male,
pubmed-meshheading:19392797-Middle Aged,
pubmed-meshheading:19392797-Pilot Projects,
pubmed-meshheading:19392797-Polymorphism, Single Nucleotide,
pubmed-meshheading:19392797-Promoter Regions, Genetic,
pubmed-meshheading:19392797-Transforming Growth Factor beta1,
pubmed-meshheading:19392797-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19392797-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
TNF, LTA and TGFB1 genotype distributions among acute graft-vs-host disease subsets after HLA-matched unrelated hematopoietic stem cell transplantation: a pilot study.
|
| pubmed:affiliation |
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|