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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-5-22
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pubmed:abstractText |
Adeno-associated virus (AAV) type 2 is an important virus due to its use as a safe and effective human gene therapy vector and its negative association with certain malignancies. AAV, a dependo-parvovirus, autonomously replicates in stratified squamous epithelium. Such tissue occurs in the nasopharynx and anogenitals, from which AAV has been clinically isolated. Related autonomous parvoviruses also demonstrate cell tropism and preferentially replicate in oncogenically transformed cells. Combining these two attributes of parvovirus tropism, squamous and malignant, we assayed if AAV might replicate in squamous cervical carcinoma cell isolates.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10364287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10440809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10531369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10632568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10666281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10729123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10873777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10881991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10982355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-10985891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-11504539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-11505462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-12050365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-1316616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-1318608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-16203022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-16300768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-16557905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-17360744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-183503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-2536816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-2549714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-2835153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-3017458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-3029431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-3031654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-6093102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-6095038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-6200995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-6808155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-7636994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-8174138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-8879120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-9525597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19389243-9573246
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2180
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19389243-Cell Line, Tumor,
pubmed-meshheading:19389243-DNA Polymerase III,
pubmed-meshheading:19389243-DNA Replication,
pubmed-meshheading:19389243-Dependovirus,
pubmed-meshheading:19389243-Female,
pubmed-meshheading:19389243-Gene Expression,
pubmed-meshheading:19389243-Humans,
pubmed-meshheading:19389243-Keratinocytes,
pubmed-meshheading:19389243-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19389243-Parvoviridae Infections,
pubmed-meshheading:19389243-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:19389243-RNA, Neoplasm,
pubmed-meshheading:19389243-Replication Protein A,
pubmed-meshheading:19389243-Replication Protein C,
pubmed-meshheading:19389243-Uterine Cervical Neoplasms,
pubmed-meshheading:19389243-Virus Replication
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pubmed:year |
2009
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pubmed:articleTitle |
Cervical cancer isolate PT3, super-permissive for adeno-associated virus replication, over-expresses DNA polymerase delta, PCNA, RFC and RPA.
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pubmed:affiliation |
Department of Internal Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, 4301 West Markham St, Little Rock, AR 72205, USA. BKang@uams.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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