| pubmed-article:1937748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1937748 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:1937748 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1937748 | pubmed:dateCreated | 1991-11-27 | lld:pubmed |
| pubmed-article:1937748 | pubmed:abstractText | Tumor necrosis factor (TNF), a macrophage product released in response to endotoxin and other stimuli, has been shown to be a central mediator of endotoxin or septic shock. However, its highly conserved and wide-ranging physiological effects suggest that it may also be an essential cytokine in the host defense against acute bacterial infection or sepsis. A single nontoxic dose of human recombinant TNF administered intravenously 24 h prior to a lethal infusion of Escherichia coli lipopolysaccharide (LPS) completely prevented acute LPS-induced hypotension, ameliorated tissue injury in the lungs and liver, and improved survival in male Fisher 344 rats. The protective effects of TNF were dose dependent and required a 24-h pretreatment interval. After the infusion of LPS, animals in both groups (TNF-treated animals and saline-pretreated controls) initially appeared acutely ill and had a similar severe metabolic acidosis, indicating that TNF did not inactivate or prevent the toxic effects of LPS. Twelve hours after the administration of TNF, the gene for manganous superoxide dismutase, a mitochondrial enzyme which scavenges toxic reactive oxygen species and is induced during conditions which generate a free radical stress, was expressed in liver tissue, suggesting that the induction of manganous superoxide dismutase may be an important in vivo protective mechanism against cellular injury during lethal endotoxemia. | lld:pubmed |
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| pubmed-article:1937748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1937748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1937748 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1937748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1937748 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1937748 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:WalkerEE | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:NortonJ AJA | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:AlexanderH... | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:JensenJ CJC | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:DohertyG MGM | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:LangsteinH... | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:KragelP JPJ | lld:pubmed |
| pubmed-article:1937748 | pubmed:author | pubmed-author:BlockM IMI | lld:pubmed |
| pubmed-article:1937748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1937748 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:1937748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1937748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1937748 | pubmed:pagination | 3889-94 | lld:pubmed |
| pubmed-article:1937748 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1937748 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1937748 | pubmed:articleTitle | Single-dose tumor necrosis factor protection against endotoxin-induced shock and tissue injury in rats. | lld:pubmed |
| pubmed-article:1937748 | pubmed:affiliation | Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1937748 | pubmed:publicationType | Journal Article | lld:pubmed |
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