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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
1991-12-26
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pubmed:databankReference |
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pubmed:abstractText |
Roughened is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photoreceptor cell determination. Roughened is a dominant gain-of-function mutation that results from a single amino acid change (Phe157 to Leu) in the Drosophila Rap1 protein. Loss of function Rap1 mutations are lethal. Drosophila Rap1 protein is 88% identical to human rap1A/K-rev1 protein, a putative antagonist of ras action.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
|
pubmed:issn |
0092-8674
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pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
67
|
|
pubmed:geneSymbol |
R
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
717-22
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1934069-Amino Acid Sequence,
pubmed-meshheading:1934069-Animals,
pubmed-meshheading:1934069-Drosophila melanogaster,
pubmed-meshheading:1934069-Eye,
pubmed-meshheading:1934069-GTP-Binding Proteins,
pubmed-meshheading:1934069-Genes, Dominant,
pubmed-meshheading:1934069-Molecular Sequence Data,
pubmed-meshheading:1934069-Mutation,
pubmed-meshheading:1934069-Sequence Alignment,
pubmed-meshheading:1934069-rap GTP-Binding Proteins
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination.
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|
pubmed:affiliation |
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
