|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2009-4-13
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|
pubmed:abstractText |
As our ongoing work, a series of peptidomimetic L-iso-glutamine derivatives derived from antineoplaston AS2-5 scaffold were prepared and their APN/CD13 and MMP-2 inhibitory activities were evaluated hereby. The results displayed that these compounds exhibited selective inhibition against APN as compared with MMP-2, with IC(50) values in micromole range. Compounds A1 and A2 showed comparable APN inhibitory activities than the positive control bestatin.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1464-3391
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3061-71
|
|
pubmed:meshHeading |
pubmed-meshheading:19339187-Antigens, CD13,
pubmed-meshheading:19339187-Antineoplastic Agents,
pubmed-meshheading:19339187-Binding Sites,
pubmed-meshheading:19339187-Glutamine,
pubmed-meshheading:19339187-Humans,
pubmed-meshheading:19339187-Inhibitory Concentration 50,
pubmed-meshheading:19339187-Models, Molecular,
pubmed-meshheading:19339187-Phenylacetates,
pubmed-meshheading:19339187-Protease Inhibitors,
pubmed-meshheading:19339187-Structure-Activity Relationship
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).
|
|
pubmed:affiliation |
School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji'nan, 250012, Shandong Province, PR China.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
