Linked Life Data

19338768

Source:http://linkedlifedata.com/resource/pubmed/id/19338768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-4-2
pubmed:abstractText
Fcalpha/muR, an Fc receptor for both IgA and IgM, is close to pIgR in gene location and has an Ig-like domain homologous to pIgR. In this study, we generated monoclonal antibodies and determined Fcalpha/muR and pIgR distributions in human intestinal tissues. Immunohistochemistry analysis showed that, unlike pIgR, which was expressed on epithelial cells of intestinal tissues, Fcalpha/muR was expressed mainly in the intestinal lamina propria and germinal centers of some lymphoid follicles. Double label immunohistochemistry analysis showed that Fcalpha/muR was expressed on intestinal macrophages and plasma cells. Fcalpha/muR was also expressed in Paneth cells. Similar expression patterns for Fcalpha/muR were observed in the small intestine, appendix, colon and rectum. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues. The different tissue distribution patterns indicate that Fcalpha/muR and pIgR have different roles in intestinal immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
381
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-52
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Human Fcalpha/muR and pIgR distribute differently in intestinal tissues.
pubmed:affiliation
Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't