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rdf:type |
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lifeskim:mentions |
umls-concept:C0005839,
umls-concept:C0006826,
umls-concept:C0008976,
umls-concept:C0205314,
umls-concept:C0278627,
umls-concept:C0302350,
umls-concept:C0599894,
umls-concept:C0679622,
umls-concept:C1456820,
umls-concept:C1513822,
umls-concept:C1514880,
umls-concept:C1709630,
umls-concept:C1880171,
umls-concept:C1998546
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-30
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pubmed:abstractText |
Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials Consortium (COTC). The COTC is a novel infrastructure to integrate cancers that naturally develop in pet dogs into the development path of new human drugs. Trials are designed to address questions challenging in conventional preclinical models and early phase human trials. Large animal spontaneous cancer models can be a valuable addition to successful studies of cancer biology and novel therapeutic drug, imaging and device development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-10598945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-10656391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-11297034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-11466715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-12604049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-12772286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-12779350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-12871057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-14623923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-15064773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-15120042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-15195007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16224236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16256156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16439306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16546688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16630824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16891239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-16964204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-17051333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-17237297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-17406616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-17631592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-18202698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-1884536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-19090007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-2821619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-8453572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-8473752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-9430587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19330034-9664085
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:ArapWadihW,
pubmed-author:HajitouAminA,
pubmed-author:HannaEngyE,
pubmed-author:HenryCarolynC,
pubmed-author:KachalaStefanS,
pubmed-author:KhannaChandC,
pubmed-author:LeblancAmyA,
pubmed-author:LibuttiSteven KSK,
pubmed-author:MazckoChristinaC,
pubmed-author:NewmanShelleyS,
pubmed-author:PaoloniMelissa CMC,
pubmed-author:PasqualiniRenataR,
pubmed-author:SorenmoKarinK,
pubmed-author:TandleAnitaA,
pubmed-author:ThammDouglasD,
pubmed-author:VailDavidD
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pubmed:issnType |
Electronic
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pubmed:volume |
4
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e4972
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19330034-Adenoviridae,
pubmed-meshheading:19330034-Animals,
pubmed-meshheading:19330034-Dogs,
pubmed-meshheading:19330034-Gene Therapy,
pubmed-meshheading:19330034-Genetic Vectors,
pubmed-meshheading:19330034-Neoplasms,
pubmed-meshheading:19330034-Neovascularization, Pathologic,
pubmed-meshheading:19330034-Oligopeptides,
pubmed-meshheading:19330034-Treatment Outcome,
pubmed-meshheading:19330034-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature.
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pubmed:affiliation |
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, N.I.H., Intramural
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