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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-4-13
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pubmed:abstractText |
Overexpression of zinc-dependent metalloproteinase, aminopeptidase N (APN/CD13), is considered to be involved in the process of tumor invasion and metastasis. Herein we describe the synthesis and in vitro enzymatic inhibition assay of antineoplaston AS2-5 scaffold peptidomimetic compounds. The results demonstrated that most of these L-iso-glutamine derivatives displayed selective inhibitory activity against APN as compared with MMP-2, with IC(50) values in the micromole range. The structure-activity relationships were also briefly discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3053-60
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pubmed:meshHeading |
pubmed-meshheading:19329328-Antigens, CD13,
pubmed-meshheading:19329328-Antineoplastic Agents,
pubmed-meshheading:19329328-Glutamine,
pubmed-meshheading:19329328-Inhibitory Concentration 50,
pubmed-meshheading:19329328-Kinetics,
pubmed-meshheading:19329328-Models, Molecular,
pubmed-meshheading:19329328-Phenylacetates,
pubmed-meshheading:19329328-Protease Inhibitors,
pubmed-meshheading:19329328-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
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pubmed:affiliation |
School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji'nan, 250012, Shandong Province, PR China.
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pubmed:publicationType |
Journal Article
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