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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-10
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pubmed:abstractText |
It has been reported that ectopically expressed interleukin-17 (IL-17) in tumor cells suppresses tumor progression through enhanced antitumor immunity in immune competent mice or promote tumor progression through an increase in inflammatory angiogenesis in immune-deficient mice. The role of endogenous IL-17 in tumor immunity remains undefined. Here we showed that tumor growth and lung metastasis were enhanced in IL-17-deficient mice, associated with decreased interferon-gamma(+) natural killer cells and tumor specific interferon-gamma(+) T cells in the tumor draining lymph nodes and tumors. Together with the published data showing that in vitro transforming growth factor-beta and IL-6-polarized Th17 cells induce tumor regression, our work supports the notion that endogenous IL-17 or/and Th17 cells may play a protective role in tumor immunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-11474253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-11877287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-12354389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-12411307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-15485625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16200070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16237115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16239919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16557264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16688162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16782025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16785554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-16818675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-17513719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-17641006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-18250191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-18354038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-18400188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-18519750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-18593946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-19589929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19289853-20339108
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0020
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-9
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Endogenous IL-17 contributes to reduced tumor growth and metastasis.
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pubmed:affiliation |
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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