Linked Life Data

19277819

Source:http://linkedlifedata.com/resource/pubmed/id/19277819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-8-7
pubmed:abstractText
Micrographic surgery is mainly used for excising basal cell carcinomas in high-risk body sites. The time-consuming process of frozen histopathology could be potentially accelerated by the application of ex vivo confocal laser scanning microscopy (CM). We examined the margins of 52 excised basal cell carcinomas by means of CM, and compared the results to conventional histological findings. For contrast enhancement, tissues were treated with 10% citric acid. The morphologic features of tumors seen in CM corresponded well to conventional light microscopy. Confocal assessment and light microscopical findings were consistent in 84.6%. If a tumor is clearly detectable by means of CM, the procedure of micrographic surgery can be accelerated. Negative confocal findings have yet to be confirmed by conventional microscopy. Applicability of CM is limited because of an inconsistent image quality that does not allow a reliable detection of small tumor nests. Further research into the handling of the samples and into specific contrast enhancement is necessary for CM to become a widely accepted procedure in micrographic surgery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1435-604X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
819-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Confocal laser scanning microscopy--evaluation of native tissue sections in micrographic surgery.
pubmed:affiliation
Department of Dermatology, University Hospital Regensburg, Regensburg, Germany. sabine.kaeb@klinik.uni-regensburg.de
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies