Linked Life Data

19268296

Source:http://linkedlifedata.com/resource/pubmed/id/19268296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2009-3-23
pubmed:abstractText
A liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method has been developed and validated to identify and quantify trace levels of cyanotoxins or microcystins (MC) in water, bivalves and fish tissue with enhanced sensitivity and specificity. The method enables confirmation and quantification of six MCs (MC-LA, LF, LR, LW, RR and YR) with a single chromatographic run. The applied chromatography also allows determination of certain MC metabolites (Desmethyl-LR and -RR). By using LC-ESI-MS/MS in multiple reaction monitoring (MRM) mode, the limit of detection and quantitation for the microcystins studied, were determined to be between 0.2 and 1 pg on column (5:1 S/N ratio). These values are below the 2 pg detection limits found in the available literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-3778
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
1216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3147-55
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Method validation of microcystins in water and tissue by enhanced liquid chromatography tandem mass spectrometry.
pubmed:affiliation
California Department of Fish and Game and Moss Landing Marine Laboratory, Rancho Cordova, CA 95670, USA. amekebri@ospr.dfg.ca.gov
pubmed:publicationType
Journal Article, Validation Studies