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| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0007120 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0887889 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0004599 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0684262 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C0336791 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:19263498 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:19263498 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19263498 | pubmed:dateCreated | 2009-4-29 | lld:pubmed |
| pubmed-article:19263498 | pubmed:abstractText | IL-7 is a cytokine that is required for T-cell development and homeostasis as well as for lymph node organogenesis. Despite the importance of IL-7 in the immune system and its potential therapeutic relevance, questions remain regarding the sites of IL-7 synthesis, specific cell types involved and molecular mechanisms regulating IL-7 expression. To address these issues, we generated two bacterial artificial chromosome (BAC) transgenic mouse lines in which IL-7 regulatory elements drive expression of either Cre recombinase or a human CD25 (hCD25) cell surface reporter molecule. Expression of the IL-7.hCD25 BAC transgene, detected by reactivity with anti-hCD25 antibody, mimicked endogenous IL-7 expression. Fetal and adult tissues from crosses between IL-7.Cre transgenic mice and Rosa26R or R26-EYFP reporters demonstrated X-gal or YFP staining in tissues known to express endogenous IL-7 at some stage during development. These transgenic lines provide novel genetic tools to identify IL-7 producing cells in various tissues and to manipulate gene expression selectively in IL-7 expressing cells. | lld:pubmed |
| pubmed-article:19263498 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19263498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19263498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19263498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19263498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19263498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19263498 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19263498 | pubmed:issn | 1526-968X | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:BedfordMark... | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:RichieEllen... | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:ReizisBorisB | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:ColesMarkM | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:CarterCarlaC | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:CardenasKimK | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:LaurentMichel... | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:NarangPriyank... | lld:pubmed |
| pubmed-article:19263498 | pubmed:author | pubmed-author:RepassJohn... | lld:pubmed |
| pubmed-article:19263498 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19263498 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:19263498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19263498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19263498 | pubmed:pagination | 281-7 | lld:pubmed |
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| pubmed-article:19263498 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19263498 | pubmed:articleTitle | IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. | lld:pubmed |
| pubmed-article:19263498 | pubmed:affiliation | Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA. | lld:pubmed |
| pubmed-article:19263498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19263498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19263498 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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