Source:http://linkedlifedata.com/resource/umls/id/C0887889
MSH: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.,NCI: Based upon the natural F plasmid of E. coli. Inserts up to 300 Kb can be cloned and stably maintained as circular molecules.