Linked Life Data

19195504

Source:http://linkedlifedata.com/resource/pubmed/id/19195504

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-2-6
pubmed:abstractText
Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1879-1913
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels.
pubmed:affiliation
Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't