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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0029418,
umls-concept:C0035696,
umls-concept:C0044602,
umls-concept:C0086597,
umls-concept:C0185117,
umls-concept:C0205225,
umls-concept:C0285761,
umls-concept:C0597861,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1451005,
umls-concept:C1456820,
umls-concept:C1523116,
umls-concept:C1705325,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2009-2-5
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pubmed:abstractText |
The effect of calyculin A (CA), a serine/threonine protein phosphatase inhibitor, on tumor necrosis factor-alpha (TNF-alpha) in primary osteoblasts was investigated to determine whether protein phosphatases could affect primary osteoblasts and if so which signaling pathways would be involved.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glyceraldehyde-3-Phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/calyculin A
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1601-0825
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
727-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19193202-Animals,
pubmed-meshheading:19193202-Animals, Newborn,
pubmed-meshheading:19193202-Blotting, Western,
pubmed-meshheading:19193202-Cell Nucleus,
pubmed-meshheading:19193202-Cells, Cultured,
pubmed-meshheading:19193202-Chromones,
pubmed-meshheading:19193202-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:19193202-Enzyme Inhibitors,
pubmed-meshheading:19193202-Glyceraldehyde-3-Phosphate Dehydrogenases,
pubmed-meshheading:19193202-Morpholines,
pubmed-meshheading:19193202-NF-kappa B,
pubmed-meshheading:19193202-Osteoblasts,
pubmed-meshheading:19193202-Oxazoles,
pubmed-meshheading:19193202-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19193202-Phosphoprotein Phosphatases,
pubmed-meshheading:19193202-Phosphorylation,
pubmed-meshheading:19193202-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19193202-RNA, Messenger,
pubmed-meshheading:19193202-Rats,
pubmed-meshheading:19193202-Rats, Wistar,
pubmed-meshheading:19193202-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19193202-Signal Transduction,
pubmed-meshheading:19193202-Time Factors,
pubmed-meshheading:19193202-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
PI3K/Akt mediates expression of TNF-alpha mRNA and activation of NF-kappaB in calyculin A-treated primary osteoblasts.
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pubmed:affiliation |
Department of Endodontics, China Medical University, Shenyang, China. drqlh@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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