rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-1-30
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pubmed:abstractText |
Acute anterior uveitis (AAU) is the most common form of uveitis and is thought to be autoimmune in nature. Recent studies have described genes that act as master controllers of autoimmunity. Protein tyrosine phosphatase type 22 (PTPN22) and Cytotoxic T lymphocyte antigen-4 (CTLA-4) are two of these genes, and single nucleotide polymorphisms (SNPs) in the genes encoding these molecules have been associated with several autoimmune diseases. In this study we have analyzed SNPs in PTPN22 and CTLA-4 in patients with AAU.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-0535
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pubmed:author |
pubmed-author:ByeLouiseL,
pubmed-author:MackensenFriederikeF,
pubmed-author:MartinTammy MTM,
pubmed-author:RosenbaumJames TJT,
pubmed-author:SmithJustine RJR,
pubmed-author:StanfordMiles RMR,
pubmed-author:SuhlerEric BEB,
pubmed-author:UreK JKJ,
pubmed-author:VaughanRobertR,
pubmed-author:WadeN KevinNK,
pubmed-author:WallaceGraham RGR
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
208-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19180256-Acute Disease,
pubmed-meshheading:19180256-Antigens, CD,
pubmed-meshheading:19180256-Autoimmunity,
pubmed-meshheading:19180256-CTLA-4 Antigen,
pubmed-meshheading:19180256-Case-Control Studies,
pubmed-meshheading:19180256-Chi-Square Distribution,
pubmed-meshheading:19180256-Female,
pubmed-meshheading:19180256-Gene Frequency,
pubmed-meshheading:19180256-Genetic Predisposition to Disease,
pubmed-meshheading:19180256-Genotype,
pubmed-meshheading:19180256-Humans,
pubmed-meshheading:19180256-Male,
pubmed-meshheading:19180256-Polymorphism, Single Nucleotide,
pubmed-meshheading:19180256-Protein Tyrosine Phosphatase, Non-Receptor Type 22,
pubmed-meshheading:19180256-Uveitis, Anterior
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pubmed:year |
2009
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pubmed:articleTitle |
Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
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pubmed:affiliation |
Oregon Health & Science University, Portland, OR, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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