Linked Life Data

19166776

Source:http://linkedlifedata.com/resource/pubmed/id/19166776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Interleukin (IL)-17 is a member of a novel family of proinflammatory cytokines produced almost exclusively by a newly recognized subclass of activated T cells called "Th17" cells. From an endodontic perspective, IL-17 potently regulates cells of the innate immune system, serving as an important bridging molecule between the adaptive and innate immune systems. The purpose of this study was to investigate the immunohistochemical localization of IL-17 during the development of periapical lesions in rats. Periapical lesions developed within 28 days after mandibular first molar pulp exposure in Sprague-Dawley rats. The animals were randomly sacrificed at 0, 7, 14, 21, and 28 days after pulpal exposure. The jaws that contained the first molar were obtained and routinely prepared for histologic analysis, immunohistochemistry, and enzyme histochemistry. From day 0 to day 28, the number of IL-17-positive cells and neutrophils ascended and peaked on day 28. Osteoclast numbers substantially multiplied from day 0 to day 14 and then gradually decreased from day 14 to day 28. In addition, the osteoclast decrease contrasted with the increased number of IL-17-positive cells and neutrophils. These findings showed that IL-17 could be observed and might possibly be involved in the inflammatory response and bone resorption of periapical tissues as well as associated with periapical lesion pathogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1878-3554
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-20
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Immunohistochemical localization of IL-17 in induced rat periapical lesions.
pubmed:affiliation
School and Hospital of Stomatology, Wuhan University, Wuhan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't