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rdf:type |
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lifeskim:mentions |
umls-concept:C0025723,
umls-concept:C0086860,
umls-concept:C0162832,
umls-concept:C0392360,
umls-concept:C0441471,
umls-concept:C0879389,
umls-concept:C1334505,
umls-concept:C1511021,
umls-concept:C1519249,
umls-concept:C1527249,
umls-concept:C1537502,
umls-concept:C1704259,
umls-concept:C1705987
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pubmed:issue |
7
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pubmed:dateCreated |
2009-6-22
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pubmed:abstractText |
To study how caretaker gene silencing relates to gatekeeper mutations in colorectal cancer (CRC), we investigated whether O6-methylguanine DNA methyltransferase (MGMT) and Human Mut-L Homologue 1 (MLH1) promoter hypermethylation are associated with APC, KRAS and BRAF mutations among 734 CRC patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1569-8041
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1216-22
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19164452-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19164452-Aged,
pubmed-meshheading:19164452-Colorectal Neoplasms,
pubmed-meshheading:19164452-CpG Islands,
pubmed-meshheading:19164452-DNA Methylation,
pubmed-meshheading:19164452-DNA Modification Methylases,
pubmed-meshheading:19164452-DNA Repair Enzymes,
pubmed-meshheading:19164452-Female,
pubmed-meshheading:19164452-Gene Silencing,
pubmed-meshheading:19164452-Genes, APC,
pubmed-meshheading:19164452-Genes, ras,
pubmed-meshheading:19164452-Humans,
pubmed-meshheading:19164452-Male,
pubmed-meshheading:19164452-Middle Aged,
pubmed-meshheading:19164452-Netherlands,
pubmed-meshheading:19164452-Nuclear Proteins,
pubmed-meshheading:19164452-Point Mutation,
pubmed-meshheading:19164452-Polymerase Chain Reaction,
pubmed-meshheading:19164452-Promoter Regions, Genetic,
pubmed-meshheading:19164452-Prospective Studies,
pubmed-meshheading:19164452-Proto-Oncogene Proteins,
pubmed-meshheading:19164452-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:19164452-Tumor Suppressor Proteins,
pubmed-meshheading:19164452-ras Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
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pubmed:affiliation |
Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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