19154620

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003299, umls-concept:C0013138, umls-concept:C0026336, umls-concept:C0030903, umls-concept:C0205263, umls-concept:C0678558
pubmed:dateCreated	2009-3-19
pubmed:abstractText	Rodent kindling induced by PTZ is a widely used model of epileptogenesis and AED testing. Overlapping pathophysiological mechanisms may underlie epileptogenesis and other neuropsychiatric conditions. Besides epilepsy, AEDs are widely used in treating various neuropsychiatric disorders. Mechanisms of AEDs' long term action in these disorders are poorly understood. We describe here a Drosophila systems model of PTZ induced locomotor plasticity that is responsive to AEDs.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101301827
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants, http://linkedlifedata.com/resource/pubmed/chemical/Pentylenetetrazole
pubmed:status	MEDLINE
pubmed:issn	1752-0509
pubmed:author	pubmed-author:MohammadFarhanF, pubmed-author:SharmaAbhayA, pubmed-author:SinghPriyankaP
pubmed:issnType	Electronic
pubmed:volume	3
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	11
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:19154620-Animals, pubmed-meshheading:19154620-Anticonvulsants, pubmed-meshheading:19154620-Disease Models, Animal, pubmed-meshheading:19154620-Drosophila, pubmed-meshheading:19154620-Epilepsy, pubmed-meshheading:19154620-Gene Expression Profiling, pubmed-meshheading:19154620-Gene Expression Regulation, pubmed-meshheading:19154620-Locomotion, pubmed-meshheading:19154620-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:19154620-Pentylenetetrazole, pubmed-meshheading:19154620-Synaptic Transmission, pubmed-meshheading:19154620-Systems Biology
pubmed:year	2009
pubmed:articleTitle	A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs.
pubmed:affiliation	Institute of Genomics and Integrative Biology, Delhi University Campus, India.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't