Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-3-4
pubmed:databankReference
pubmed:abstractText
During a large mumps virus (MuV) outbreak which occurred in the Palestinian refugee camps of the West Bank, 68.1% (2,636/3,871) of the cases were vaccinated with one dose of trivalent measles, mumps, and rubella (MMR) vaccine. Attack rates by camp ranged from less than 1 case per 1,000 people in the population to 43/1,000 (overall, 11/1,000). The outbreak lasted from December 2003 to June 2005, with two peaks, one from April to May 2004 and the other from March to April 2005. To control the outbreak, a mass MMR vaccination campaign was conducted in May 2005. Evaluation of the immune status of cases (n=59) and healthy controls (n=51) revealed high levels of mumps immunoglobulin G (IgG) and a low MuV-specific IgM in clinical cases indicative of a booster immune response. This suggested a secondary rather than a primary infection due to the insufficient protection conferred by the single vaccine dose included in the vaccination program. This prediction was further confirmed by the low seroprevalence (68.6%) found in the healthy control group, which was below the threshold level required for MuV herd immunity. Mumps diagnosis was established mainly by reverse transcription-PCR in clinical samples obtained within 48 h from the onset of disease. Of the parotid fluids and nasopharyngeal aspirates analyzed, 92% were positive for MuV RNA, while only 33% of the urine samples were positive. Phylogenetic analysis of the MuV SH gene identified the outbreak strain as the H genotype, which has been in circulation worldwide at least since 1989.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-10063655, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-10438373, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-11602779, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-11824989, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-11838903, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-12069019, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-13601835, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-14980256, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15042653, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15042654, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15246601, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15301032, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15847931, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-15959834, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-16498380, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-16503474, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-16601665, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-16884835, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-17498856, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-17608960, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-18205215, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-18354822, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-18403766, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-18419451, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-18440271, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-1861205, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-4008922, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-4598423, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-7714488, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-8096942, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-8277201, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-9260679, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144793-9801337
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1098-660X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
560-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:19144793-Humans, pubmed-meshheading:19144793-Middle East, pubmed-meshheading:19144793-Adolescent, pubmed-meshheading:19144793-Infant, pubmed-meshheading:19144793-Aged, pubmed-meshheading:19144793-Child, pubmed-meshheading:19144793-Arabs, pubmed-meshheading:19144793-Urine, pubmed-meshheading:19144793-Nasopharynx, pubmed-meshheading:19144793-Parotid Gland, pubmed-meshheading:19144793-Child, Preschool, pubmed-meshheading:19144793-Female, pubmed-meshheading:19144793-Refugees, pubmed-meshheading:19144793-Male, pubmed-meshheading:19144793-Mumps, pubmed-meshheading:19144793-Adult, pubmed-meshheading:19144793-Disease Outbreaks, pubmed-meshheading:19144793-Mumps virus, pubmed-meshheading:19144793-Middle Aged, pubmed-meshheading:19144793-Young Adult, pubmed-meshheading:19144793-Immunoglobulin G, pubmed-meshheading:19144793-Immunoglobulin M, pubmed-meshheading:19144793-Genotype, pubmed-meshheading:19144793-Antibodies, Viral, pubmed-meshheading:19144793-Molecular Sequence Data
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