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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-8-19
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pubmed:abstractText |
In this study, we analyzed the gene expression profile of fibroblast-like synoviocyte (FLS) cultures from the temporomandibular joint (TMJ) to identify candidate genes associated with intracapsular pathologic conditions of TMJ. Cyclooxygenase (COX)-2 was one of the genes in FLS upregulated following stimulation by interleukin (IL)-1beta, a cytokine thought to play a key role in several pathological conditions. This study investigated the expression of COX-1 and COX-2 in cultured human FLS and rat TMJ synovium following stimulation with IL-1beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1600-0714
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
584-90
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pubmed:meshHeading |
pubmed-meshheading:19141058-Adult,
pubmed-meshheading:19141058-Animals,
pubmed-meshheading:19141058-Cells, Cultured,
pubmed-meshheading:19141058-Cyclooxygenase 1,
pubmed-meshheading:19141058-Cyclooxygenase 2,
pubmed-meshheading:19141058-Disease Models, Animal,
pubmed-meshheading:19141058-Female,
pubmed-meshheading:19141058-Fibroblasts,
pubmed-meshheading:19141058-Gene Expression Profiling,
pubmed-meshheading:19141058-Gene Expression Regulation,
pubmed-meshheading:19141058-Humans,
pubmed-meshheading:19141058-Immunohistochemistry,
pubmed-meshheading:19141058-Interleukin-1beta,
pubmed-meshheading:19141058-Male,
pubmed-meshheading:19141058-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19141058-RNA,
pubmed-meshheading:19141058-Rats,
pubmed-meshheading:19141058-Synovial Membrane,
pubmed-meshheading:19141058-Synovitis,
pubmed-meshheading:19141058-Temporomandibular Joint,
pubmed-meshheading:19141058-Temporomandibular Joint Disorders,
pubmed-meshheading:19141058-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Expression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint.
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pubmed:affiliation |
Department of Maxillofacial Surgery, Nihon University School of Dentistry, Matsudo, Chiba 271-8587, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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