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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-1
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pubmed:abstractText |
Secretory clusterin (sCLU)/apolipoprotein J is an extracellular chaperone that has been functionally implicated in DNA repair, cell cycle regulation, apoptotic cell death, and tumorigenesis. It exerts a prosurvival function against most therapeutic treatments for cancer and is currently an antisense target in clinical trials for tumor therapy. However, the molecular mechanisms underlying its function remained largely unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-59
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pubmed:meshHeading |
pubmed-meshheading:19118032-Antigens, Nuclear,
pubmed-meshheading:19118032-Cell Line, Tumor,
pubmed-meshheading:19118032-Clusterin,
pubmed-meshheading:19118032-Cytosol,
pubmed-meshheading:19118032-DNA-Binding Proteins,
pubmed-meshheading:19118032-Genes, p53,
pubmed-meshheading:19118032-Humans,
pubmed-meshheading:19118032-Mitochondria,
pubmed-meshheading:19118032-Organelles,
pubmed-meshheading:19118032-RNA, Small Interfering,
pubmed-meshheading:19118032-bcl-2-Associated X Protein
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pubmed:year |
2009
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pubmed:articleTitle |
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex.
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pubmed:affiliation |
Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece. itrougakos@eie.gr
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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