Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-3-17
pubmed:abstractText
Thymic mesenchymal cells are known to be important for the development of the early fetal thymus into a functionally mature organ supporting T cell differentiation. We examined the expression of mesenchymal markers: pan-mesenchymal marker ER-TR7, desmin, alpha-smooth muscle actin (alpha-SMA), and alpha- and beta-chain of platelet-derived growth factor receptor (PDGFRalpha, PDGFRbeta) in thymi of normal adult mice. Desmin and ER-TR7 revealed specific staining in the capsule, septa, and perivascular cells. Most perivascular cells highly expressed PDGFRbeta at the same levels as desmin. Low expression of PDGFRalpha was detected in the capsule, intralobular septa, and some perivascular cells of normal adult thymi. alpha-SMA, used to identify vascular smooth muscle cells, was detectable on arterioles and some large venules but not on capillaries. Thus, desmin, PDGFRalpha, and PDGFRbeta were localized in the capsule, septa, and perivascular cells in thymus of adult mouse, although there were differences in the expression level among these markers. On the other hand, the expression of mesenchymal markers was detectable in the region of the thymic medullary epithelium of lymphotoxin beta receptor-deficient mice and plt/plt mice, indicating that mesenchymal cells were abnormally localized in the region. These results suggest that disorganization of the medullary epithelium may be accompanied by aberrant distribution of mesenchyme in adult mouse thymus.
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1554
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-82
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed-meshheading:19110482-Actins, pubmed-meshheading:19110482-Animals, pubmed-meshheading:19110482-Biological Markers, pubmed-meshheading:19110482-Desmin, pubmed-meshheading:19110482-Epithelial Cells, pubmed-meshheading:19110482-Fluorescent Antibody Technique, pubmed-meshheading:19110482-Lymphotoxin beta Receptor, pubmed-meshheading:19110482-Mesoderm, pubmed-meshheading:19110482-Mice, pubmed-meshheading:19110482-Mice, Inbred BALB C, pubmed-meshheading:19110482-Mice, Inbred C57BL, pubmed-meshheading:19110482-Mice, Knockout, pubmed-meshheading:19110482-Microscopy, Confocal, pubmed-meshheading:19110482-Muscle, Smooth, Vascular, pubmed-meshheading:19110482-Myocytes, Smooth Muscle, pubmed-meshheading:19110482-Receptor, Platelet-Derived Growth Factor alpha, pubmed-meshheading:19110482-Receptor, Platelet-Derived Growth Factor beta, pubmed-meshheading:19110482-Thymus Gland
pubmed:year
2009
pubmed:articleTitle
Localization of mesenchymal cells in adult mouse thymus: their abnormal distribution in mice with disorganization of thymic medullary epithelium.
pubmed:affiliation
Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1, Gakuen, Musashimurayama, Tokyo 208-0011, Japan. odaka@nih.go.jp
pubmed:publicationType
Journal Article