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pubmed:abstractText |
Caspase-3, a principal apoptotic effector that cleaves the majority of cellular substrates, is an important medicinal target for the treatment of cancers and neurodegenerative diseases. Large amounts of the protein are required for drug discovery research. However, previous efforts to express the full-length caspase-3 gene in E. coli have been unsuccessful.
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pubmed:affiliation |
Nanobiotechnology Division, University of Science and Technology, Yuseong, Daejeon, 305-806, Korea. jin0305@kribb.re.kr
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