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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-2
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pubmed:abstractText |
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-related disorders. Details of the structure-activity relationships and biological activity from the first structural class of this scaffold will be discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BhatRameshR,
pubmed-author:BodinePeter V NPV,
pubmed-author:CommonsThomas JTJ,
pubmed-author:FukayamaShoichiS,
pubmed-author:GoljerIgorI,
pubmed-author:KernJeffrey CJC,
pubmed-author:KrishnamurthyGirijaG,
pubmed-author:MagoldaRonald LRL,
pubmed-author:MooreWilliam JWJ,
pubmed-author:NogleLisaL,
pubmed-author:PittsKeithK,
pubmed-author:StaufferBarbB,
pubmed-author:TrybulskiEugene JEJ,
pubmed-author:WelmakerGregory SGS,
pubmed-author:WilsonMatthewM
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-16
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pubmed:meshHeading |
pubmed-meshheading:19072540-Animals,
pubmed-meshheading:19072540-Cell Line, Tumor,
pubmed-meshheading:19072540-Genes, Reporter,
pubmed-meshheading:19072540-Humans,
pubmed-meshheading:19072540-Inhibitory Concentration 50,
pubmed-meshheading:19072540-Isomerism,
pubmed-meshheading:19072540-Mice,
pubmed-meshheading:19072540-Molecular Structure,
pubmed-meshheading:19072540-Piperidines,
pubmed-meshheading:19072540-Protein Binding,
pubmed-meshheading:19072540-Proteins,
pubmed-meshheading:19072540-Signal Transduction,
pubmed-meshheading:19072540-Skull,
pubmed-meshheading:19072540-Structure-Activity Relationship,
pubmed-meshheading:19072540-Sulfanilamides,
pubmed-meshheading:19072540-Wnt Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
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pubmed:affiliation |
Chemical and Screening Sciences, Wyeth Research, Collegeville, Pennsylvania 19426, USA. moorew2@wyeth.com
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pubmed:publicationType |
Journal Article
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