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rdf:type |
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lifeskim:mentions |
umls-concept:C0014239,
umls-concept:C0028754,
umls-concept:C0038435,
umls-concept:C0040300,
umls-concept:C0043096,
umls-concept:C0392756,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-27
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pubmed:abstractText |
Obesity is associated with insulin resistance and type 2 diabetes, although the mechanisms linking these pathologies remain undetermined. Recent studies in rodent models revealed endoplasmic reticulum (ER) stress in adipose and liver tissues and demonstrated that ER stress could cause insulin resistance. Therefore, we tested whether these stress pathways were also present in obese human subjects and/or regulated by weight loss.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DK-37948,
http://linkedlifedata.com/resource/pubmed/grant/DK-56341,
http://linkedlifedata.com/resource/pubmed/grant/DK52539,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK040561-13,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK056341-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK037948-22,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK052539-11,
http://linkedlifedata.com/resource/pubmed/grant/T32 ES007155-24,
http://linkedlifedata.com/resource/pubmed/grant/T32-ES-007155-24,
http://linkedlifedata.com/resource/pubmed/grant/UL1 RR024992-01,
http://linkedlifedata.com/resource/pubmed/grant/UL1-RR-024992
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-10480510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-10553015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-10650002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-10722755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-10999830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-11287357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-12198715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-12829627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-13833973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-15486293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-16046292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-16925250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-16931765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17135584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17167474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17229948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17268797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17565364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17699733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17709641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-17715408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-18567819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-18728164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-19246600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-9398739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-9506738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066313-9627371
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-700
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:19066313-Adipose Tissue,
pubmed-meshheading:19066313-Endoplasmic Reticulum,
pubmed-meshheading:19066313-Female,
pubmed-meshheading:19066313-Follow-Up Studies,
pubmed-meshheading:19066313-Gastric Bypass,
pubmed-meshheading:19066313-Glucose Clamp Technique,
pubmed-meshheading:19066313-Humans,
pubmed-meshheading:19066313-Hyperinsulinism,
pubmed-meshheading:19066313-Insulin Resistance,
pubmed-meshheading:19066313-Liver,
pubmed-meshheading:19066313-Male,
pubmed-meshheading:19066313-Middle Aged,
pubmed-meshheading:19066313-Muscle, Skeletal,
pubmed-meshheading:19066313-Obesity,
pubmed-meshheading:19066313-Stress, Physiological
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pubmed:year |
2009
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pubmed:articleTitle |
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.
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pubmed:affiliation |
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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