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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010453,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0040691,
umls-concept:C0086661,
umls-concept:C0871261,
umls-concept:C1185714,
umls-concept:C1366765,
umls-concept:C1527194,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2009-2-23
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pubmed:abstractText |
Although transforming growth factor beta1 (TGFbeta1) is known to be a potent inhibitor of proliferation in most cell types, it accelerates proliferation in certain mesenchymal cells, such as articular chondrocytes and nucleus pulposus cells. The low ability for self-renewal of nucleus pulposus cells is one obstacle in developing new therapeutic options for intervertebral disc diseases, and utilizing cytokines is one of the strategies to regulate nucleus pulposus cell proliferation. However, the precise cell cycle progression and molecular mechanisms by which TGFbeta1 stimulates cell growth remain unclear. The aim of this study was to elucidate a mechanism that enables cell proliferation with TGFbeta1 stimulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1478-6362
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R140
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19061498-Animals,
pubmed-meshheading:19061498-Cell Proliferation,
pubmed-meshheading:19061498-Cells, Cultured,
pubmed-meshheading:19061498-Female,
pubmed-meshheading:19061498-Flavonoids,
pubmed-meshheading:19061498-Genes, myc,
pubmed-meshheading:19061498-Intervertebral Disc,
pubmed-meshheading:19061498-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19061498-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19061498-Phosphorylation,
pubmed-meshheading:19061498-Rats,
pubmed-meshheading:19061498-Rats, Sprague-Dawley,
pubmed-meshheading:19061498-Transforming Growth Factor beta1
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pubmed:year |
2008
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pubmed:articleTitle |
Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF beta-1 in cultured rat nucleus pulposus cells.
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pubmed:affiliation |
Division of Organogenesis, Research Center for Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan. tnakai@is.icc.u-tokai.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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