Source:http://linkedlifedata.com/resource/pubmed/id/19054371
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
2008-12-4
|
pubmed:abstractText |
In this study, we investigated the five polymorphic Alu loci located within human major histocompatibility complex (MHC) class I region in 445 individuals from four distinct Chinese populations: Hunan Han, Inner Mongolia Han, Inner Mongolia Mongol and Guangdong Han populations, with an emphasis on the linkage disequilibrium (LD) between Alu insertions and human leukocyte antigen (HLA)-A, Cw and B loci in a southern (Hunan Province) and a northern (Inner Mongolia Autonomous Region) Chinese Han population. Our data showed that (a) the allele and haplotype frequencies of Alu and HLA-A loci did not differ significantly between the two southern Chinese Han populations and showed remarkable homogeneity in the two northern Chinese populations; (b) AluyHG had the highest insertion rate and HLA-A*02 harboring the single AluyHG insertion was most frequent among Alu insertion-bearing haplotypes in all four populations; (c) haplotypes AluyHF insertion-HLA-A*26, AluyHG insertion-HLA-A*02 and AluyHJ insertion-HLA-A*24 were in significant LD across the four groups and (d) haplotype AluyMICB insertion-HLA-Cw*06 was in significant LD in both populations, while significant LD of haplotypes AluyMICB insertion-HLA-B*54 and AluyMICB insertion-HLA-B*48 was only observed in the Hunan Han population and the Inner Mongolia Han population, respectively. Haplotype HLA-B*48-MICA gene deletion-AluyMICB insertion was observed at a frequency of about 3.85% in the latter population. Our data, together with previous reports on several Asian-Oceanian populations suggest the identity by descent of several common HLA-A allelic lineages in these modern human populations. The novel population-specific LD patterns uncovered in this study also shed new insight into HLA evolution and haplotype origin.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1399-0039
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
72
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
559-67
|
pubmed:meshHeading |
pubmed-meshheading:19054371-Alleles,
pubmed-meshheading:19054371-Alu Elements,
pubmed-meshheading:19054371-China,
pubmed-meshheading:19054371-Gene Frequency,
pubmed-meshheading:19054371-Genotype,
pubmed-meshheading:19054371-HLA-A Antigens,
pubmed-meshheading:19054371-HLA-B Antigens,
pubmed-meshheading:19054371-HLA-C Antigens,
pubmed-meshheading:19054371-Haplotypes,
pubmed-meshheading:19054371-Humans,
pubmed-meshheading:19054371-Linkage Disequilibrium,
pubmed-meshheading:19054371-Polymorphism, Genetic,
pubmed-meshheading:19054371-Population
|
pubmed:year |
2008
|
pubmed:articleTitle |
Polymorphic insertions in 5 Alu loci within the major histocompatibility complex class I region and their linkage disequilibria with HLA alleles in four distinct populations in mainland China.
|
pubmed:affiliation |
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, Hunan, China. tianwei2@yahoo.com
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|