Up- and down-regulation of inflammatory response was described in blood cells from septic patients, according to the stage of sepsis and the cells evaluated. This study aimed to evaluate the Toll-like receptor (TLR) signaling pathway gene expression in peripheral blood mononuclear cells (PBMC) and neutrophils in patients throughout the different stages of sepsis.
Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock.
Division of Infectious Diseases, Escola Paulista de Medicina, Federal University of Sao Paulo, UNIFESP, Rua Pedro de Toledo no 781, 15o andar, Sao Paulo, SP, Brazil. rsalomao@unifesp.br