Source:http://linkedlifedata.com/resource/pubmed/id/19018975
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-7-29
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pubmed:abstractText |
Gallbladder cancer (GBC) usually arises against the background of gallstone disease, which may be causatively related to supersaturation of cholesterol in bile. An imbalance in cholesterol homeostasis because of oversecretion of cholesterol in the gallbladder promotes gallstone formation. The excretion of cholesterol from the liver is regulated by adenosine triphosphate-binding cassette transporter ABCG8. A common genetic polymorphism D19H of ABCG8 associated with gallstone disease may be causatively related to the genetic predisposition of GBC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1478-3231
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
831-7
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pubmed:meshHeading |
pubmed-meshheading:19018975-ATP-Binding Cassette Transporters,
pubmed-meshheading:19018975-Cholesterol,
pubmed-meshheading:19018975-Gallbladder Neoplasms,
pubmed-meshheading:19018975-Gene Frequency,
pubmed-meshheading:19018975-Genetic Predisposition to Disease,
pubmed-meshheading:19018975-Genotype,
pubmed-meshheading:19018975-Humans,
pubmed-meshheading:19018975-Odds Ratio,
pubmed-meshheading:19018975-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19018975-Polymorphism, Single Nucleotide
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pubmed:year |
2009
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pubmed:articleTitle |
Single nucleotide polymorphism in the ABCG8 transporter gene is associated with gallbladder cancer susceptibility.
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pubmed:affiliation |
Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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