| pubmed-article:19013539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C1013701 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:19013539 | lifeskim:mentions | umls-concept:C0057454 | lld:lifeskim |
| pubmed-article:19013539 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19013539 | pubmed:dateCreated | 2009-5-15 | lld:pubmed |
| pubmed-article:19013539 | pubmed:abstractText | The matrix metalloproteinases (MMP-9 and MMP-2) in aortic smooth muscle cells (SMC) play key roles in the pathogenesis atherosclerosis. The SMC migration into the vascular wall via the bloodstream is directly linked with MMP-9 expression. Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris Hoffm. and has been known inhibit the expression of MMP-9 in tumor necrosis factor-alpha (TNF-alpha) stimulated human aortic smooth muscle cells (HASMC). In this study, DPT was purified and demonstrated to inhibit the MMP-9/2 activities in TNF-alpha-induced HASMC. In addition, MMP-9 expression and migration was strongly inhibited by DPT in TNF-alpha-induced HASMC. To examine whether TNF-alpha-induced MMP-9 expressions are involved with migrations of HASMC, reverse transcription-polymerase chain reaction (RT-PCR) and luciferase-tagged promoter analysis were applied. These experiments revealed that DPT inhibited the mRNA transcription of MMP-9 gene expression. Furthermore, Western blot analysis indicated that the TNF-alpha-induced phosphorylation of extracellular signal regulated kinase 1 and 2 (ERK1/2), p38 and c-Jun N-terminal kinase (JNK) were strongly inhibited by DPT. From these results, it is concluded that DPT has an inhibitory activities on migration and MMP-2/9 activities, and MMP-9 transcription in HASMC. | lld:pubmed |
| pubmed-article:19013539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19013539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19013539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19013539 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19013539 | pubmed:issn | 1879-3649 | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:UngerC LCL | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:LeeYoung-Choo... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:KimCheorl-HoC... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:LeeIn-SeonIS | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:KimSung-HoonS... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:ChangHyeun-Wo... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:MoonTae... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:ChangYoung-Ch... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:KimJeong-RanJ... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:SuhSeok-JongS... | lld:pubmed |
| pubmed-article:19013539 | pubmed:author | pubmed-author:ChoiHong-SeoH... | lld:pubmed |
| pubmed-article:19013539 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19013539 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:19013539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19013539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19013539 | pubmed:pagination | 13-20 | lld:pubmed |
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| pubmed-article:19013539 | pubmed:meshHeading | pubmed-meshheading:19013539... | lld:pubmed |
| pubmed-article:19013539 | pubmed:meshHeading | pubmed-meshheading:19013539... | lld:pubmed |
| pubmed-article:19013539 | pubmed:meshHeading | pubmed-meshheading:19013539... | lld:pubmed |
| pubmed-article:19013539 | pubmed:meshHeading | pubmed-meshheading:19013539... | lld:pubmed |
| pubmed-article:19013539 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19013539 | pubmed:articleTitle | Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. | lld:pubmed |
| pubmed-article:19013539 | pubmed:affiliation | Department of Biological Science, Sungkyunkwan University, Chunchun-Dong 300, Jangan-Gu, Suwon City, Kyunggi-Do 440-746, Republic of Korea. | lld:pubmed |
| pubmed-article:19013539 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19013539 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:19013539 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
