Linked Life Data

19003864

Source:http://linkedlifedata.com/resource/pubmed/id/19003864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23-24
pubmed:dateCreated
2008-12-18
pubmed:abstractText
Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide and is often characterized by aggressive tumour behaviour and poor prognosis. One of the major etiologies is hepatitis B or C virus (HBV or HCV) infections. In order to better comprehend the molecular mechanisms involved in HCC progression, we performed a systematic analysis on moderately and poorly differentiated human HCC tissues using 2-D DIGE coupled to MALDI-TOF/TOF MS. A total of 52 and 26 proteins were found to be dysregulated in moderately and poorly differentiated HCC tissues, respectively. For the first time, the over-expression of a novel protein family, far upstream binding proteins (FUBPs) was identified in both stages of HCC and confirmed by western blots. FUBPs are of particular interest due to their transcriptional activity on the oncogene, c-myc. It has generally been accepted that c-myc plays an important role in HCC progression but its exact activators remain poorly understood. Interestingly, we also observed elevated c-myc levels in the tissues used in this study by western blot analysis. We therefore propose that the FUBP family of proteins may be one of the possible upstream players that are involved in modulating the c-myc levels in HCC tumorigenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1615-9861
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5086-96
pubmed:meshHeading
pubmed-meshheading:19003864-Amino Acid Sequence, pubmed-meshheading:19003864-Blotting, Western, pubmed-meshheading:19003864-Carcinoma, Hepatocellular, pubmed-meshheading:19003864-DNA Helicases, pubmed-meshheading:19003864-DNA-Binding Proteins, pubmed-meshheading:19003864-Electrophoresis, Gel, Two-Dimensional, pubmed-meshheading:19003864-Humans, pubmed-meshheading:19003864-Liver Neoplasms, pubmed-meshheading:19003864-Models, Biological, pubmed-meshheading:19003864-Molecular Sequence Data, pubmed-meshheading:19003864-Protein Isoforms, pubmed-meshheading:19003864-Proto-Oncogene Proteins c-myc, pubmed-meshheading:19003864-RNA-Binding Proteins, pubmed-meshheading:19003864-Reproducibility of Results, pubmed-meshheading:19003864-Spectrometry, Mass, Matrix-Assisted Laser..., pubmed-meshheading:19003864-Trans-Activators, pubmed-meshheading:19003864-Up-Regulation
pubmed:year
2008
pubmed:articleTitle
2-D DIGE profiling of hepatocellular carcinoma tissues identified isoforms of far upstream binding protein (FUBP) as novel candidates in liver carcinogenesis.
pubmed:affiliation
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't