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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-14
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pubmed:abstractText |
The transcription of the Drosophila melanogaster 68C salivary gland glue gene Sgs-3 involves the interaction of a distal and a proximal regulatory region. These are marked in vivo by a specific chromatin structure which is established sequentially during development, starting early in embryogenesis. The distal region is characterized by a stage- and tissue-specific DNase I hypersensitive site. A stage- and tissue-specific factor, GEBF-I, binds in this region and is missing in 2B5 mutant larvae which lack Sgs-3 transcripts. This binding involves the simultaneous interaction with two distinct DNA sequences which induces conformational changes in the protein. Salivary glands acquire competence to respond to ecdysone in the mid-third larval instar, whereafter the hormone rapidly induces both the GEBF-I protein and Sgs-3 transcription.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2107982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2110921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-212715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2433681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2504635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2721493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2981637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-2995982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3007111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3028780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3052270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3085955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3108882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3118208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3123322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3128796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3138416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-3208750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-4208797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6088056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6207936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6214314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6269071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6275366,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6774262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-6783464,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1898764-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:geneSymbol |
Sgs-3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
523-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1898764-Age Factors,
pubmed-meshheading:1898764-Animals,
pubmed-meshheading:1898764-Base Sequence,
pubmed-meshheading:1898764-Chromatin,
pubmed-meshheading:1898764-Chromosome Mapping,
pubmed-meshheading:1898764-DNA-Binding Proteins,
pubmed-meshheading:1898764-Drosophila melanogaster,
pubmed-meshheading:1898764-Ecdysone,
pubmed-meshheading:1898764-Enhancer Elements, Genetic,
pubmed-meshheading:1898764-Gene Expression Regulation,
pubmed-meshheading:1898764-Genes,
pubmed-meshheading:1898764-Glue Proteins, Drosophila,
pubmed-meshheading:1898764-Molecular Sequence Data,
pubmed-meshheading:1898764-Oligonucleotides,
pubmed-meshheading:1898764-Protein Binding,
pubmed-meshheading:1898764-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1898764-Restriction Mapping,
pubmed-meshheading:1898764-Transcription, Genetic,
pubmed-meshheading:1898764-Transcription Factors
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pubmed:year |
1991
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pubmed:articleTitle |
Sgs-3 chromatin structure and trans-activators: developmental and ecdysone induction of a glue enhancer-binding factor, GEBF-I, in Drosophila larvae.
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pubmed:affiliation |
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184 de Biologie Moléculaire, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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