Linked Life Data

18979536

Source:http://linkedlifedata.com/resource/pubmed/id/18979536

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-4-28
pubmed:abstractText
Originally developed as contrast agents for ultrasound imaging and diagnostics, in the past years, microbubbles have made their way back from the patients' bedside to the researcher's laboratory. Microbubbles are currently believed to have great potential as carriers for drugs, small molecules, nucleic acids, and proteins. This review provides insight into this intriguing new frontier from the perspective of the pharmaceutical scientist. First, basic aspects on the application of ultrasound-targeted microbubble destruction for drug delivery will be presented. Next, we will review the recently applied approaches for manufacturing and drug-loading microbubbles. Important quality issues and characterization techniques for advanced microbubble formulation will be discussed. Finally, we will provide an assessment of the prospects for microbubbles in drug and gene therapy, illustrating the problems and requirements for their future development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-6017
pubmed:author
pubmed:copyrightInfo
(c) 2008 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1935-61
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Microbubbles as ultrasound triggered drug carriers.
pubmed:affiliation
Department of Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians University-Munich, Butenandtstr. 5-13, D-81377 Munich, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't