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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-10-24
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pubmed:abstractText |
Fatty acid synthase (FAS) is a recently discovered molecule involved in the energy supply to normal cells. FAS is overexpressed in neoplastic tissues because of their increased energy needs. We explored the immunohistochemical expression of FAS, Ki-67 and p53 in squamous cell carcinomas (SCC) of the larynx and their association with clinicopathological features and outcome. Specimens from 43 patients with SCC were evaluated. Statistical analysis revealed an association between poorly differentiated laryngeal carcinomas and FAS expression (p<0.005) and between FAS and Ki-67 overexpression (p<0.001). Finally, FAS expression was associated with overall survival (p<0.001). We suggest that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0393-6155
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pubmed:author |
pubmed-author:CastellsCC,
pubmed-author:CensiFF,
pubmed-author:De VincentiisMM,
pubmed-author:Della RoccaCC,
pubmed-author:Di CelloPP,
pubmed-author:GalloAA,
pubmed-author:HayN MNM,
pubmed-author:IzzoLL,
pubmed-author:LeopizziMM,
pubmed-author:NataliziSS,
pubmed-author:PietrasantaDD,
pubmed-author:SardellaBB,
pubmed-author:SoldoPP,
pubmed-author:ZottiG CGC
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-81
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pubmed:meshHeading |
pubmed-meshheading:18949744-Adult,
pubmed-meshheading:18949744-Aged,
pubmed-meshheading:18949744-Carcinoma, Squamous Cell,
pubmed-meshheading:18949744-Fatty Acid Synthetase Complex,
pubmed-meshheading:18949744-Female,
pubmed-meshheading:18949744-Follow-Up Studies,
pubmed-meshheading:18949744-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18949744-Genes, p53,
pubmed-meshheading:18949744-Humans,
pubmed-meshheading:18949744-Immunohistochemistry,
pubmed-meshheading:18949744-Ki-67 Antigen,
pubmed-meshheading:18949744-Laryngeal Neoplasms,
pubmed-meshheading:18949744-Male,
pubmed-meshheading:18949744-Middle Aged,
pubmed-meshheading:18949744-Tumor Suppressor Protein p53
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pubmed:articleTitle |
Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx.
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pubmed:affiliation |
Department of Otorhinolaryngology, La Sapienza University, Rome, Italy.
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pubmed:publicationType |
Journal Article
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