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pubmed-article:1894635 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
pubmed-article:1894635 | pubmed:issue | 26 | lld:pubmed |
pubmed-article:1894635 | pubmed:dateCreated | 1991-10-21 | lld:pubmed |
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pubmed-article:1894635 | pubmed:abstractText | Act-2 is a cytokine that belongs to a superfamily of structurally related proteins. Act-2 expression is rapidly induced in T cells, B cells, and monocytes upon mitogenic stimulation. The Act-2 genomic locus is on chromosome 17q. The exons and exon/intron splice junctions have been sequenced, as have the sequences upstream of exon 1. A classical TATA box is located immediately upstream of the transcription initiation site. The upstream sequences possess promoter activity and can be functionally activated after treatment of Jurkat T cells with phythohemagglutinin plus phorbol myristrate acetate. In addition, Act-2 promoter chloramphenicol acetyltransferase constructs are expressed in human T cell lymphotropic virus type I (HTLV-I)-infected MT-2 cells and in Jurkat cells which can be induced to express the transactivator gene (tax) product of HTLV-I. | lld:pubmed |
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pubmed-article:1894635 | pubmed:language | eng | lld:pubmed |
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pubmed-article:1894635 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:1894635 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1894635 | pubmed:month | Sep | lld:pubmed |
pubmed-article:1894635 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:CevarioS JSJ | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:SeuanezH NHN | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:NapolitanoMM | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:ModiW SWS | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:LeonardW JWJ | lld:pubmed |
pubmed-article:1894635 | pubmed:author | pubmed-author:GnarraJ RJR | lld:pubmed |
pubmed-article:1894635 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1894635 | pubmed:day | 15 | lld:pubmed |
pubmed-article:1894635 | pubmed:volume | 266 | lld:pubmed |
pubmed-article:1894635 | pubmed:geneSymbol | tax | lld:pubmed |
pubmed-article:1894635 | pubmed:geneSymbol | Act-2 | lld:pubmed |
pubmed-article:1894635 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1894635 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1894635 | pubmed:pagination | 17531-6 | lld:pubmed |
pubmed-article:1894635 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:1894635 | pubmed:year | 1991 | lld:pubmed |
pubmed-article:1894635 | pubmed:articleTitle | The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization. | lld:pubmed |
pubmed-article:1894635 | pubmed:affiliation | Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
pubmed-article:1894635 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1894635 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:1894635 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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