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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0017337,
umls-concept:C0017428,
umls-concept:C0020094,
umls-concept:C0039371,
umls-concept:C0079189,
umls-concept:C0162326,
umls-concept:C0209338,
umls-concept:C0475264,
umls-concept:C0678594,
umls-concept:C0679058,
umls-concept:C1337091,
umls-concept:C1547699,
umls-concept:C1704900,
umls-concept:C2700640
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pubmed:issue |
26
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|
pubmed:dateCreated |
1991-10-21
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pubmed:databankReference |
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pubmed:abstractText |
Act-2 is a cytokine that belongs to a superfamily of structurally related proteins. Act-2 expression is rapidly induced in T cells, B cells, and monocytes upon mitogenic stimulation. The Act-2 genomic locus is on chromosome 17q. The exons and exon/intron splice junctions have been sequenced, as have the sequences upstream of exon 1. A classical TATA box is located immediately upstream of the transcription initiation site. The upstream sequences possess promoter activity and can be functionally activated after treatment of Jurkat T cells with phythohemagglutinin plus phorbol myristrate acetate. In addition, Act-2 promoter chloramphenicol acetyltransferase constructs are expressed in human T cell lymphotropic virus type I (HTLV-I)-infected MT-2 cells and in Jurkat cells which can be induced to express the transactivator gene (tax) product of HTLV-I.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9258
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
266
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pubmed:geneSymbol |
Act-2,
tax
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17531-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1894635-Amino Acid Sequence,
pubmed-meshheading:1894635-Base Sequence,
pubmed-meshheading:1894635-Blotting, Southern,
pubmed-meshheading:1894635-Cell Line,
pubmed-meshheading:1894635-Chemokine CCL4,
pubmed-meshheading:1894635-Chemokines, CC,
pubmed-meshheading:1894635-Chromosome Mapping,
pubmed-meshheading:1894635-Chromosomes, Human, Pair 17,
pubmed-meshheading:1894635-Cytokines,
pubmed-meshheading:1894635-DNA, Viral,
pubmed-meshheading:1894635-Exons,
pubmed-meshheading:1894635-Gene Expression Regulation, Viral,
pubmed-meshheading:1894635-Genes, pX,
pubmed-meshheading:1894635-Human T-lymphotropic virus 1,
pubmed-meshheading:1894635-Humans,
pubmed-meshheading:1894635-Introns,
pubmed-meshheading:1894635-Macrophage Inflammatory Proteins,
pubmed-meshheading:1894635-Molecular Sequence Data,
pubmed-meshheading:1894635-Promoter Regions, Genetic,
pubmed-meshheading:1894635-Proteins,
pubmed-meshheading:1894635-Tumor Cells, Cultured
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pubmed:year |
1991
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pubmed:articleTitle |
The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.
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pubmed:affiliation |
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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