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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-10-22
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pubmed:abstractText |
There is an increased risk of failure of engraftment following nonmyeloablative conditioning. Sensitization resulting from failed bone marrow transplantation (BMT) remains a major challenge for secondary BMT. Approaches to allow successful retransplantation would have significant benefits for BMT candidates living with chronic diseases. We used a mouse model to investigate the effect of preparative regimens at primary BMT on outcome for secondary BMT. We found that conditioning with TBI or recipient T cell lymphodepletion at primary BMT did not promote successful secondary BMT. In striking contrast, successful secondary BMT could be achieved in mice conditioned with anti-CD154 costimulatory molecule blockade at first BMT. Blockade of CD154 alone or combined with T cell depletion inhibits generation of the humoral immune response after primary BMT, as evidenced by abrogation of production of anti-donor Abs. The humoral barrier is dominant in sensitization resulting from failed BMT, because almost all CFSE-labeled donor cells were killed at 0.5 and 3 h in sensitized recipients in in vivo cytotoxicity assay, reflecting Ab-mediated cytotoxicity. CD154:CD40 costimulatory blockade used at primary BMT promotes allogeneic engraftment in secondary BMT after engraftment failure at first BMT. The prevention of generation of anti-donor Abs at primary BMT is critical for successful secondary BMT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-10455873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-10742157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-10754303,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-15240675,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-15972631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-16081787,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-16861947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-16880451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-16888094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-17018854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-17222778,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-17460568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-17827394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-1922237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-2300104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-2684931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-3906651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-6361574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-7516405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-7594573,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-8665076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-8970958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9203418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9256196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9288126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9446633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9597126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941252-9922369
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6616-24
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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