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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response and thus may correlate with clinical presentation and severity of CD. The aim of this study was to determine the correlation between HLA-DQ/DR-based genotypes and the variation in phenotypes of the disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1502-7708
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18932050-Celiac Disease,
pubmed-meshheading:18932050-Child,
pubmed-meshheading:18932050-Child, Preschool,
pubmed-meshheading:18932050-Female,
pubmed-meshheading:18932050-Genetic Predisposition to Disease,
pubmed-meshheading:18932050-Genotype,
pubmed-meshheading:18932050-Glutens,
pubmed-meshheading:18932050-HLA-DQ Antigens,
pubmed-meshheading:18932050-HLA-DR Antigens,
pubmed-meshheading:18932050-HLA-DR3 Antigen,
pubmed-meshheading:18932050-Humans,
pubmed-meshheading:18932050-Male,
pubmed-meshheading:18932050-Mass Screening,
pubmed-meshheading:18932050-Phenotype,
pubmed-meshheading:18932050-Retrospective Studies,
pubmed-meshheading:18932050-Severity of Illness Index,
pubmed-meshheading:18932050-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.
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pubmed:affiliation |
Department of Paediatric Gastroenterology, Leiden University Medical Centre, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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