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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-24
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pubmed:abstractText |
Osteoprotegerin (OPG) has been associated with abdominal aortic aneurysm (AAA) expansion. Angiotensin II (AngII) receptor blockade has been shown to reduce OPG expression in human AAA tissue. Interaction between vascular AngII and OPG was further examined using cell culture and the AngII-infused ApoE(-/-) mouse AAA model. The ability of peroxisome proliferator-activated receptor-gamma (PPARgamma) activation to target OPG as potential therapy for AAA was also investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-17
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pubmed:meshHeading |
pubmed-meshheading:18931513-Angiotensin II,
pubmed-meshheading:18931513-Animals,
pubmed-meshheading:18931513-Aortic Aneurysm, Abdominal,
pubmed-meshheading:18931513-Apolipoproteins E,
pubmed-meshheading:18931513-Humans,
pubmed-meshheading:18931513-Interleukin-6,
pubmed-meshheading:18931513-Male,
pubmed-meshheading:18931513-Matrix Metalloproteinase 9,
pubmed-meshheading:18931513-Mice,
pubmed-meshheading:18931513-Mice, Inbred C57BL,
pubmed-meshheading:18931513-Osteoprotegerin,
pubmed-meshheading:18931513-PPAR gamma,
pubmed-meshheading:18931513-Receptor, Angiotensin, Type 1
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pubmed:year |
2009
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pubmed:articleTitle |
Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm.
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pubmed:affiliation |
Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, Australia.
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pubmed:publicationType |
Journal Article
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