|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
20
|
|
pubmed:dateCreated |
2008-10-17
|
|
pubmed:abstractText |
Arachidonic acid metabolism via the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways modulates cell growth and apoptosis. Many studies have examined the effects of COX inhibitors on human colorectal cancer, but the role of 5-LOX in colonic cancer development has not been well studied. The purpose of this study was to evaluate the expression of 5-LOX in colonic polyps and cancer and the effect of 5-LOX inhibition on colon cancer cell proliferation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AdrianThomas ATA,
pubmed-author:BellRichard HRH,
pubmed-author:BentremDavid JDJ,
pubmed-author:DingXian-ZhongXZ,
pubmed-author:KennedyTimothy JTJ,
pubmed-author:MelstromLaleh GLG,
pubmed-author:RaoSambasiva MSM,
pubmed-author:SalabatMohammad RMR,
pubmed-author:StrouchMatthewM,
pubmed-author:TalamontiMark SMS,
pubmed-author:TernentCharles ACA,
pubmed-author:WittRichard CRC
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6525-30
|
|
pubmed:meshHeading |
pubmed-meshheading:18927292-Adenoma,
pubmed-meshheading:18927292-Animals,
pubmed-meshheading:18927292-Apoptosis,
pubmed-meshheading:18927292-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:18927292-Cell Proliferation,
pubmed-meshheading:18927292-Colonic Neoplasms,
pubmed-meshheading:18927292-Colonic Polyps,
pubmed-meshheading:18927292-Disease Models, Animal,
pubmed-meshheading:18927292-Female,
pubmed-meshheading:18927292-Humans,
pubmed-meshheading:18927292-Immunoenzyme Techniques,
pubmed-meshheading:18927292-Lipoxygenase Inhibitors,
pubmed-meshheading:18927292-Mice,
pubmed-meshheading:18927292-Mice, Inbred BALB C,
pubmed-meshheading:18927292-Mice, Nude,
pubmed-meshheading:18927292-Nordihydroguaiaretic Acid,
pubmed-meshheading:18927292-RNA, Messenger,
pubmed-meshheading:18927292-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18927292-Thymidine,
pubmed-meshheading:18927292-Tumor Cells, Cultured,
pubmed-meshheading:18927292-Xenograft Model Antitumor Assays
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
|
|
pubmed:affiliation |
Department of Surgery and Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
|
