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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-15
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pubmed:abstractText |
Although the influence of VKORC1 and CYP2C9 polymorphisms on warfarin response has been studied, variability in dose explained by CYP2C9 and VKORC1 is lower among African-Americans compared with European-Americans. This has lead investigators to hypothesize that assessment of VKORC1 haplotypes may help capture a greater proportion of the variability in dose for this under-represented group. However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18855533-10858659,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1744-8042
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1445-58
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pubmed:dateRevised |
2011-2-10
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pubmed:meshHeading |
pubmed-meshheading:18855533-Adult,
pubmed-meshheading:18855533-African Americans,
pubmed-meshheading:18855533-Aged,
pubmed-meshheading:18855533-Anticoagulants,
pubmed-meshheading:18855533-Cohort Studies,
pubmed-meshheading:18855533-European Continental Ancestry Group,
pubmed-meshheading:18855533-Female,
pubmed-meshheading:18855533-Forecasting,
pubmed-meshheading:18855533-Haplotypes,
pubmed-meshheading:18855533-Humans,
pubmed-meshheading:18855533-Male,
pubmed-meshheading:18855533-Middle Aged,
pubmed-meshheading:18855533-Mixed Function Oxygenases,
pubmed-meshheading:18855533-Polymorphism, Genetic,
pubmed-meshheading:18855533-Warfarin
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pubmed:year |
2008
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pubmed:articleTitle |
VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.
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pubmed:affiliation |
Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC-312, Birmingham AL 35294-0021, USA. nlimdi@uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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