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VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

Source:http://linkedlifedata.com/resource/pubmed/id/18855533

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Authors

Arnett DK, Beasley TM, Goldstein JA, Flockhart DA, Rieder MJ, Acton RT, Liu N, Crowley MR, Limdi NA

Affiliation

Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC-312, Birmingham AL 35294-0021, USA. nlimdi@uab.edu

Abstract

Although the influence of VKORC1 and CYP2C9 polymorphisms on warfarin response has been studied, variability in dose explained by CYP2C9 and VKORC1 is lower among African-Americans compared with European-Americans. This has lead investigators to hypothesize that assessment of VKORC1 haplotypes may help capture a greater proportion of the variability in dose for this under-represented group. However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort.

PMID
18855533

Publication types

Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural