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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-10-9
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pubmed:abstractText |
5-Lipoxygenase (5-LO) catalyzes the rate-limiting step of the biosynthesis of proinflammatory leukotrienes from arachidonic acid (AA) and has been associated with atherosclerosis in animal models and humans. We previously reported that variants of a 5-LO promoter repeat polymorphism were associated with carotid atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high dietary n-3 fatty acids.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-10084106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-11706027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-11744518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-11884288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-12142344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-12491911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-12552108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-12668490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-14501583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-14656734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-14702425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-15640973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16043658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16200066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16282974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16506957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16624897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16640955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16698924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-16778124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17101540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17110605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17304054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17373938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17576065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17579092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-17768297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-9062372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18842779-9698605
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1938-3207
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
934-40
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:18842779-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:18842779-Arachidonic Acid,
pubmed-meshheading:18842779-Atherosclerosis,
pubmed-meshheading:18842779-Case-Control Studies,
pubmed-meshheading:18842779-Confidence Intervals,
pubmed-meshheading:18842779-Diet,
pubmed-meshheading:18842779-Female,
pubmed-meshheading:18842779-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18842779-Gene Frequency,
pubmed-meshheading:18842779-Genotype,
pubmed-meshheading:18842779-Humans,
pubmed-meshheading:18842779-Male,
pubmed-meshheading:18842779-Middle Aged,
pubmed-meshheading:18842779-Myocardial Infarction,
pubmed-meshheading:18842779-Nutrigenomics,
pubmed-meshheading:18842779-Odds Ratio,
pubmed-meshheading:18842779-Polymorphism, Genetic,
pubmed-meshheading:18842779-RNA, Messenger,
pubmed-meshheading:18842779-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.
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pubmed:affiliation |
Department of Preventive Medicine and the Institute for Genetic Medicine, the University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9075, USA. hallayee@usc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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