pubmed-article:18839428 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C1556085 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C2347026 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C0370003 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
pubmed-article:18839428 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
pubmed-article:18839428 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:18839428 | pubmed:dateCreated | 2008-12-8 | lld:pubmed |
pubmed-article:18839428 | pubmed:abstractText | Human chromosome 8q24.21 has been implicated as a susceptibility region for colorectal cancer (CRC) as a result of genome-wide association and candidate gene studies. To assess the impact of molecular variants at 8q24.21 upon the CRC risk of German individuals and to refine the disease-associated region, a total of 2,713 patients with operated CRC (median age at diagnosis: 63 years) were compared with 2,718 sex-matched control individuals (median age at inclusion: 65 years). Information on microsatellite instability in tumors was available for 901 patients. Association analysis of SNPs rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively. For both polymorphisms, the odds ratio was estimated to be 1.50 (95% CI: 1.29-1.75) under a recessive disease model. The strongest candidate interval, outside of which significance dropped by more than 4 orders of magnitude, was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb. In a subgroup analysis, the disease association was found to be more pronounced in MSI-stable tumors (odds ratio: 1.71). Our study confirms the role of genetic variation at 8q24.21 as a risk factor for CRC and localizes the corresponding susceptibility gene to a 17 kb candidate region. | lld:pubmed |
pubmed-article:18839428 | pubmed:language | eng | lld:pubmed |
pubmed-article:18839428 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18839428 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18839428 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18839428 | pubmed:month | Jan | lld:pubmed |
pubmed-article:18839428 | pubmed:issn | 1097-0215 | lld:pubmed |
pubmed-article:18839428 | pubmed:author | pubmed-author:LerchMarkus... | lld:pubmed |
pubmed-article:18839428 | pubmed:author | pubmed-author:SchreiberStef... | lld:pubmed |
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pubmed-article:18839428 | pubmed:author | pubmed-author:JohnUlrichU | lld:pubmed |
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pubmed-article:18839428 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:18839428 | pubmed:day | 1 | lld:pubmed |
pubmed-article:18839428 | pubmed:volume | 124 | lld:pubmed |
pubmed-article:18839428 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18839428 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18839428 | pubmed:pagination | 75-80 | lld:pubmed |
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pubmed-article:18839428 | pubmed:year | 2009 | lld:pubmed |
pubmed-article:18839428 | pubmed:articleTitle | Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. | lld:pubmed |
pubmed-article:18839428 | pubmed:affiliation | Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany. | lld:pubmed |
pubmed-article:18839428 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18839428 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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