Source:http://linkedlifedata.com/resource/pubmed/id/18839428
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2008-12-8
|
| pubmed:abstractText |
Human chromosome 8q24.21 has been implicated as a susceptibility region for colorectal cancer (CRC) as a result of genome-wide association and candidate gene studies. To assess the impact of molecular variants at 8q24.21 upon the CRC risk of German individuals and to refine the disease-associated region, a total of 2,713 patients with operated CRC (median age at diagnosis: 63 years) were compared with 2,718 sex-matched control individuals (median age at inclusion: 65 years). Information on microsatellite instability in tumors was available for 901 patients. Association analysis of SNPs rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively. For both polymorphisms, the odds ratio was estimated to be 1.50 (95% CI: 1.29-1.75) under a recessive disease model. The strongest candidate interval, outside of which significance dropped by more than 4 orders of magnitude, was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb. In a subgroup analysis, the disease association was found to be more pronounced in MSI-stable tumors (odds ratio: 1.71). Our study confirms the role of genetic variation at 8q24.21 as a risk factor for CRC and localizes the corresponding susceptibility gene to a 17 kb candidate region.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1097-0215
|
| pubmed:author |
pubmed-author:BroschMarioM,
pubmed-author:BuchStephanS,
pubmed-author:CatalcaliJasminJ,
pubmed-author:EgbertsJan HendrikJH,
pubmed-author:ElSharawyAbdouA,
pubmed-author:FändrichFredF,
pubmed-author:FölschUlrich RUR,
pubmed-author:FrankeAndreA,
pubmed-author:HampeJochenJ,
pubmed-author:HellmigStephanS,
pubmed-author:HenoppTobiasT,
pubmed-author:JohnUlrichU,
pubmed-author:KalthoffHolgerH,
pubmed-author:KatalinicAlexanderA,
pubmed-author:KrawczakMichaelM,
pubmed-author:LerchMarkus MMM,
pubmed-author:MathiakMicaelaM,
pubmed-author:RuetherAndreasA,
pubmed-author:SchafmayerClemensC,
pubmed-author:SchniewindBodoB,
pubmed-author:SchreiberStefanS,
pubmed-author:SiposBenceB,
pubmed-author:TepelJürgenJ,
pubmed-author:VölzkeHenryH,
pubmed-author:von SchönfelsWitigoW
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
124
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
75-80
|
| pubmed:meshHeading |
pubmed-meshheading:18839428-Adolescent,
pubmed-meshheading:18839428-Adult,
pubmed-meshheading:18839428-Aged,
pubmed-meshheading:18839428-Aged, 80 and over,
pubmed-meshheading:18839428-Case-Control Studies,
pubmed-meshheading:18839428-Chromosomes, Human, Pair 8,
pubmed-meshheading:18839428-Colorectal Neoplasms,
pubmed-meshheading:18839428-Female,
pubmed-meshheading:18839428-Genetic Predisposition to Disease,
pubmed-meshheading:18839428-Germany,
pubmed-meshheading:18839428-Humans,
pubmed-meshheading:18839428-Male,
pubmed-meshheading:18839428-Microsatellite Repeats,
pubmed-meshheading:18839428-Middle Aged,
pubmed-meshheading:18839428-Polymorphism, Single Nucleotide
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample.
|
| pubmed:affiliation |
Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|